Dragon Quest XI continues the gameplay of previous games in the series, in which players explore worlds and fight against various monsters, including the ability to explore high areas. Before entering battle, players can also toggle between the 3D and 2D graphical styles. The game features the series' traditional turn-based battle system.

A young man who lives in the calm village of Ishi. The protagonist, who began a coming-of-age ceremony when he turned 16, learns an astonishing truth. He is the reincarnation of the “hero” that once saved the world, someone who carries the burden of a major mission… In order to confirm his fate with his own eyes, the protagonist leaves his hometown and steps forward to the vast world.