A 3D platform video game and the third installment in the Ratchet & Clank series. The gameplay is similar to previous games in the series but introduces new features such as a new control system and more levels in the upgrade system for weapons. It follows Ratchet and Clank's adventure through a fictional universe to defeat a robotic villain, Dr. Nefarious, who intends to destroy all organic life. Characters such as Dr. Nefarious and Sasha, a Cazar starship captain who helps Ratchet throughout the game, are introduced, and a number of characters return from the original Ratchet & Clank.

The third-installment invades the online universe with new, explosive weapons and unique gadgets that are out of this constellation. Ratchet and Clank return to planet Veldin, (the setting of the original Ratchet & Clank) where they’ve been called upon by the president of the galaxy to stop Dr. Nefarious as he plots to exterminate all organic life. Together with the Q-Force and Captain Qwark, Ratchet and Clank set off on another intergalactic quest to uncover the schemes of the sinister Dr. Nefarious and save the galaxy again!